Wenxin Keli attenuates ischemia一induced ventricular arrhythmias in rats

XI WANG, XIN WANG,YONGWEI GU, TENG WANG and CONGXIN HUANG
( Department of Cardiology Renmin Hospital of Wuhan University, Wuhan, PR. China

Abstract: Wenxin Keli is the first state一sanctioned traditional Chinese medicine (TCM)一based
antiarrhythmic drug. The present study aimed to examine whether long-term treatment with Wenxin
Keli reduces ischemia-induced ventricular arrhythmias in rats in vivo, and if so, which mechanisms are
involved. Male rats were treated with either saline (control group) or Wenxin Keli for 3 weeks and were
subjected to myocardial ischemia for 30 min with assessment of the resulting ventricular arrhythmias.
The L-type calcium current  and transient outward potassium current were measured by the patch clamp technique in normal rat cardiac ventricular myocytes. During the 30-min ischemia, Wenxin
Keli significantly reduced the incidence of ventricular fibrillation(VF) (P<0.05). The number of ventricular
tachycardia (VT)+VF episodes and the severity of arrhythmias were significantly reduced by Wenxin Keli
administration compared to the control group (P<0.05). In addition, Wenxin Keli inhibited I(cal) and I(to) in a
concentration-dependent manner. These results suggest that Tong-term treatment with Wenxin Keli may
attenuate ischemia-induced ventricular arrhythmias in rats and that I(cal) and I(to)  may be involved in this
attenuation.

Keywords: wenxin keli,ventricular arrhythmias, L-type calcium current, transient outward potassium current, patch clamp techniques, traditional Chinese medicines

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